Mouse Vtcn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vtcn1
Locus ID	242122
Kit Components	GA215029G1, Vtcn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215029G2, Vtcn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215029G3, Vtcn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_178594
Synonyms	B7h4; B7s1; B7x; BC032925
Summary	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.[UniProtKB/Swiss-Prot Function]

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