Mouse Chrm2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Chrm2
Locus ID	243764
Kit Components	GA215147G1, Chrm2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215147G2, Chrm2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215147G3, Chrm2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_203491
Synonyms	AChR-M2; Chrm-2; M2
Summary	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity).[UniProtKB/Swiss-Prot Function]

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