Mouse Wdr59 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wdr59
Locus ID	319481
Kit Components	GA216291G1, Wdr59 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216291G2, Wdr59 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216291G3, Wdr59 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001170742, NM_001170743, NM_176923
Synonyms	5430401O09Rik; Cdw12
Summary	As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.[UniProtKB/Swiss-Prot Function]

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