Mouse Sbf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sbf2
Locus ID	319934
Kit Components	GA216383G1, Sbf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216383G2, Sbf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216383G3, Sbf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_177324, NM_178769
Synonyms	4833411B01Rik; AA414977; AI317167; B430219L04Rik; mMTMH1; Mtmr13
Summary	Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2 (PubMed:16399794). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794).[UniProtKB/Swiss-Prot Function]

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