Mouse Atp11c activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atp11c
Locus ID	320940
Kit Components	GA216592G1, Atp11c gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216592G2, Atp11c gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216592G3, Atp11c gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001798, NM_001037863, NM_001359002
Synonyms	A330005H02Rik; AI315324; Ig
Summary	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate phosphatidylserine (PS) flipping in pro-B cells (PubMed:21423172). May be involved in the transport of cholestatic bile acids (PubMed:21518881).[UniProtKB/Swiss-Prot Function]

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