Mouse Gpr52 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gpr52
Locus ID	620246
Kit Components	GA217942G1, Gpr52 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217942G2, Gpr52 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217942G3, Gpr52 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001146330, NM_001368668
Synonyms	EG620246
Summary	G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).[UniProtKB/Swiss-Prot Function]

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