SIRT3 Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	SIRT3
Locus ID	23410
Kit Components	KN200190G1, SIRT3 gRNA vector 1 in pCas-Guide CRISPR vector KN200190G2, SIRT3 gRNA vector 2 in pCas-Guide CRISPR vector KN200190BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Reference Data
RefSeq	NM_001017524, NM_012239, NM_001370312, NM_001370314, NM_001370316, NM_001370318, NM_001370319, NM_001370325, NR_163386, NR_163388, NR_163389, NR_163390, NR_163391, NR_163393, NR_163394, NR_163398, NR_163399, NR_163400, NR_163401, NM_001370310, NM_001370315, NM_001370317, NM_001370320, NM_001370321, NM_001370322, NM_001370323, NM_001370324, NR_163387, NR_163392, NR_163395, NR_163396, NR_163397, NR_163402
Synonyms	SIR2L3
Summary	SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

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