Galectin 3 (LGALS3) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA	RFP-BSD
Symbol	Galectin 3
Locus ID	3958
Kit Components	KN208785G1, Galectin 3 gRNA vector 1 in pCas-Guide CRISPR vector KN208785G2, Galectin 3 gRNA vector 2 in pCas-Guide CRISPR vector KN208785RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector
Reference Data
RefSeq	NM_001177388, NM_002306, NR_003225, NM_001357678
Synonyms	CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2
Summary	This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

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