RAMAC (NM_031452) Human Mass Spec Standard

Specifications

Product Data
Description	FAM103A1 MS Standard C13 and N15-labeled recombinant protein (NP_113640)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200815
Predicted MW	14.4 kDa
Protein Sequence	Sequence Link (showhide) >RC200815 protein sequence Red=Cloning site Green=Tags(s) MTDTAEAVPKFEEMFASRFTENDKEYQEYLKRPPESPPIVEEWNSRAGGNQRNRGNRLQDNRQFRGRDNR WGWPSDNRSNQWHGRSWGNNYPQHRQEPYYPQQYGHYGYNQRPPYGYY TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_113640
RefSeq Size	1588
RefSeq ORF	354
Synonyms	C15orf18; FAM103A1; HsT19360; RAM; RAMMET
Locus ID	83640
Cytogenetics	15q25.2
Summary	Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306).[UniProtKB/Swiss-Prot Function]

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