SPSB4 (NM_080862) Human Mass Spec Standard
CAT#: PH303566
SPSB4 MS Standard C13 and N15-labeled recombinant protein (NP_543138)
View other "SPSB4" proteins (3)
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CNY 19520.00
CNY 3080.00
Specifications
Product Data | |
Description | SPSB4 MS Standard C13 and N15-labeled recombinant protein (NP_543138) |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC203566 |
Predicted MW | 30.2 kDa |
Protein Sequence |
>RC203566 protein sequence
Red=Cloning site Green=Tags(s) MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDD DRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESW GWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLY PVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
Reference Data | |
RefSeq | NP_543138 |
RefSeq Size | 2455 |
RefSeq ORF | 819 |
Synonyms | SSB-4; SSB4 |
Locus ID | 92369 |
Cytogenetics | 3q23 |
Summary | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC409014 | SPSB4 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY409014 | Transient overexpression lysate of splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4) |
CNY 3080.00 |
|
TP303566 | Recombinant protein of human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), 20 µg |
CNY 2900.00 |