SIAH2 (NM_005067) Human Mass Spec Standard

Specifications

Product Data
Description	SIAH2 MS Standard C13 and N15-labeled recombinant protein (NP_005058)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203802
Predicted MW	34.4 kDa
Protein Sequence	Sequence Link (showhide) >RC203802 representing NM_005067 Red=Cloning site Green=Tags(s) MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQ HHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKY ATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDI NLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATP RSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005058
RefSeq Size	2632
RefSeq ORF	972
Synonyms	hSiah2
Locus ID	6478
Cytogenetics	3q25.1
Summary	This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transcription Factors

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