EXOSC1 (NM_016046) Human Mass Spec Standard

Specifications

Product Data
Description	EXOSC1 MS Standard C13 and N15-labeled recombinant protein (NP_057130)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC206007
Predicted MW	21.5 kDa
Protein Sequence	Sequence Link (showhide) >RC206007 protein sequence Red=Cloning site Green=Tags(s) MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAI VTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQS NYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057130
RefSeq Size	1150
RefSeq ORF	585
Synonyms	CGI-108; CSL4; Csl4p; p13; PCH1F; SKI4; Ski4p
Locus ID	51013
Cytogenetics	10q24.1
Summary	This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Protein Pathways	RNA degradation

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