TPK1 (NM_022445) Human Mass Spec Standard

Specifications

Product Data
Description	TPK1 MS Standard C13 and N15-labeled recombinant protein (NP_071890)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC209721
Predicted MW	27.2 kDa
Protein Sequence	Sequence Link (showhide) >RC209721 protein sequence Red=Cloning site Green=Tags(s) MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFING DFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVN TLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCSQVTTTGLKWNLTNDVLA FGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_071890
RefSeq Size	2449
RefSeq ORF	729
Synonyms	HTPK1; PP20; THMD5
Locus ID	27010
Cytogenetics	7q35
Summary	The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Thiamine metabolism

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