BDH2 (NM_020139) Human Mass Spec Standard

Specifications

Product Data
Description	BDH2 MS Standard C13 and N15-labeled recombinant protein (NP_064524)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC210586
Predicted MW	26.8 kDa
Protein Sequence	Sequence Link (showhide) >RC210586 protein sequence Red=Cloning site Green=Tags(s) MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQIDQFAN EVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKG VVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGR FATAEEIAMLCVYLASDESTYVTGNPVIIDGGWSL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_064524
RefSeq Size	2936
RefSeq ORF	735
Synonyms	DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR; UNQ6308
Locus ID	56898
Cytogenetics	4q24
Summary	Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome
Protein Pathways	Butanoate metabolism, Metabolic pathways, Synthesis and degradation of ketone bodies

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