DCTN3 (NM_007234) Human Mass Spec Standard

Specifications

Product Data
Description	DCTN3 MS Standard C13 and N15-labeled recombinant protein (NP_009165)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC210658
Predicted MW	21.1 kDa
Protein Sequence	Sequence Link (showhide) >RC210658 protein sequence Red=Cloning site Green=Tags(s) MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDP EYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQC VEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_009165
RefSeq Size	857
RefSeq ORF	558
Synonyms	DCTN-22; DCTN22
Locus ID	11258
Cytogenetics	9p13.3
Summary	This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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