CTNS (NM_004937) Human Mass Spec Standard

Specifications

Product Data
Description	CTNS MS Standard C13 and N15-labeled recombinant protein (NP_004928)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC213151
Predicted MW	41.6 kDa
Protein Sequence	Sequence Link (showhide) >RC213151 representing NM_004937 Red=Cloning site Green=Tags(s) MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITIL ELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRSSAISIINQVIGWIYFVAWSI SFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSL HAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVK YFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFF IQHFCLYRKRPGYDQLN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_004928
RefSeq Size	2611
RefSeq ORF	1101
Synonyms	CTNS-LSB; PQLC4; SLC66A4
Locus ID	1497
Cytogenetics	17p13.2
Summary	This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome

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