SARM (SARM1) (NM_015077) Human Mass Spec Standard

Specifications

Product Data
Description	SARM1 MS Standard C13 and N15-labeled recombinant protein (NP_055892)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC215903
Predicted MW	79.2 kDa
Protein Sequence	Sequence Link (showhide) RC215903
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_055892
RefSeq Size	7001
RefSeq ORF	2172
Synonyms	hSARM1; HsTIR; MyD88-5; SAMD2; SARM
Locus ID	23098
Cytogenetics	17q11.2
Summary	Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome

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