Luteinizing Hormone beta (LHB) (NM_000894) Human Mass Spec Standard

Specifications

Product Data
Description	LHB MS Standard C13 and N15-labeled recombinant protein (NP_000885)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC216028
Predicted MW	15.35 kDa
Protein Sequence	Sequence Link (showhide) >RC216028 representing NM_000894 Red=Cloning site Green=Tags(s) MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLP PLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLF L TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000885
RefSeq Size	523
RefSeq ORF	423
Synonyms	CGB4; HH23; LSH-B; LSH-beta
Locus ID	3972
Cytogenetics	19q13.33
Summary	This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	GnRH signaling pathway, Neuroactive ligand-receptor interaction

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