DDI2 (NM_032341) Human Mass Spec Standard
CAT#: PH318468
DDI2 MS Standard C13 and N15-labeled recombinant protein (NP_115717)
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CNY 19520.00
Specifications
Product Data | |
Description | DDI2 MS Standard C13 and N15-labeled recombinant protein (NP_115717) |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC218468 |
Predicted MW | 44.3 kDa |
Protein Sequence |
>RC218468 representing NM_032341
Red=Cloning site Green=Tags(s) MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGD VVILRQKENADPRPPVQFPNLPRIDFSSIAVPGTSSPRQRQPPGTQQSHSSPGEITSSPQGLDNPALLRD MLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDI RQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAG IAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQT TFLPEGELPECARLAYGAGREDVRPEEIADQELAEALQKSAEDAERQKP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
Reference Data | |
RefSeq | NP_115717 |
RefSeq Size | 1759 |
RefSeq ORF | 1197 |
Locus ID | 84301 |
Cytogenetics | 1p36.21 |
Summary | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TP318468 | Recombinant protein of human DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae) (DDI2), 20 µg |
CNY 2900.00 |