DDI2 (NM_032341) Human Mass Spec Standard

CAT#: PH318468

DDI2 MS Standard C13 and N15-labeled recombinant protein (NP_115717)



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CNY 19520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description DDI2 MS Standard C13 and N15-labeled recombinant protein (NP_115717)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC218468
Predicted MW 44.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_115717
RefSeq Size 1759
RefSeq ORF 1197
Locus ID 84301
Cytogenetics 1p36.21
Summary Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612).[UniProtKB/Swiss-Prot Function]
Protein Families Druggable Genome
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