Haptoglobin (HP) (NM_005143) Human Mass Spec Standard

CAT#: PH323612

HP MS Standard C13 and N15-labeled recombinant protein (NP_005134)



  View other "Haptoglobin" proteins (7)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description HP MS Standard C13 and N15-labeled recombinant protein (NP_005134)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC223612
Predicted MW 45.21 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_005134
RefSeq Size 1433
RefSeq ORF 1218
Synonyms BP; HP2ALPHA2; HPA1S
Locus ID 3240
Cytogenetics 16q22.2
Summary This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Protein Families Druggable Genome, Protease, Secreted Protein, Transmembrane
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