ADAR Mutant (K744R) Human Recombinant Protein

Specifications

Product Data
Description	Purified mutant recombinant protein of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 4, mutation at（K744R)
Species	Human
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	A DNA sequence from TrueORF clone, RC219761, encoding the full-length of ADAR(K744R)
Tag	Myc-DDK
Predicted MW	103.5 kDa
Concentration	>0.05 µg/µL as determined by microplate Bradford method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_001020278.1
Locus ID	103
Refseq Size	6532
Cytogenetics	1q21.3
Refseq ORF	2793
Synonyms	ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136
Summary	This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Protein Families	Druggable Genome
Protein Pathways	Cytosolic DNA-sensing pathway

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