N6AMT1 / HEMK2 (1-214, His-Tag) Human Protein
CNY 14920.00
货期*
详询
规格
Cited in 2 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
|
Tag | His-Tag |
Predicted MW | 25.3 kDa (237aa) confirmed by MALDI-TOF |
Concentration | 0.25mg/ml (determined by Bradford assay) |
Purity | > 85% by SDS-PAGE |
Buffer | Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT |
Applications | SDS-PAGE |
Protein Description | Recombinant human N6ATM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_037372 |
Locus ID | 29104 |
UniProt ID | Q9Y5N5 |
Cytogenetics | 21q21.3 |
Synonyms | HemK methyltransferase family member 2, HemK methyltransferase family member 2, C21orf127, HEMK2, MTQ2, N6AMT, PRED28 |
Summary | This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014] |
Protein Families | Druggable Genome |
Citations (2)
The use of this Proteins has been cited in the following citations: |
---|
The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
,null,
Nature neuroscience
,PubMed ID 30778148
[N6AMT1]
|
Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 ( N6AMT1 ) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity
,null,
Environmental Health Perspectives
,PubMed ID 21193388
[N6AMT1]
|
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