Ska3 (NM_198605) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR217957 protein sequence Red=Cloning site Green=Tags(s) MNPIQSFHCKLRGLATTLDSETARLLRALDGEDSDFEDSPGRILHDLHSEVQTLKDNVNALLDEARLENQ ESTRFKKATKILMEKNSADVRKLREFFQKYGYQARDKEDSGCEHRVNNSTPELAVCKDIQKAGVKELSDP CVPSGSVSEEPLRSPQLSDFGLQRYIISQVPANPPQTAASLKEERVAETPPAKDPSVQVLKTPRCALRMD DFECETPKLEHFGISEHTMCLNEDYTMGLKNMKNIKSSLLSGVSGEAIGTGPVTSDNSFAIPGPIIQQME ENDVEYVSSPLPPKFCTPGLKIPSTMDRTDLVSIDYPLSKPNSSSTDLEIKDCVPLILNSDECYQSFAEP PSSAITSCENFATPSPPKVTAIPEDILQMITKHSSNLASPLDVKVMPRRKGTRGAANKENW TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	45.4 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_941007
Locus ID	219114
UniProt ID	Q8C263
Refseq Size	2260
Cytogenetics	14 C3
Refseq ORF	1233
Synonyms	F630043A04Rik
Summary	Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.[UniProtKB/Swiss-Prot Function]

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