Acmsd (NM_001033041) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR219865 representing NM_001033041 Red=Cloning site Green=Tags(s) MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMIKDGKLFRVIQQNCWDPEVRIREMNQKGVTV QALSTVPVMFSYWAKPKDTLELCQFLNNDLAATVARYPRRFVGLGTLPMQAPELAVEEMERCVKALGFPG IQIGSHINTWDLNDPELFPIYAAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTMAICSMIMGG VFEKFPKLKVCFAHGGGAFPFTIGRIAHGFNMRPDLCAQDNPSDPRKYLGSFYTDSLVHDPLSLKLLTDV IGKDKVMLGTDYPFPLGEQEPGKLIESMAEFDEETKDKLTAGNALAFLGLERKLFE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	38.5 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_001028213
Locus ID	266645
UniProt ID	Q8R519
Refseq Size	2303
Cytogenetics	1 E3
Refseq ORF	1008
Summary	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.[UniProtKB/Swiss-Prot Function]

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