TRAF4AF1 (KNSTRN) (NM_001142762) Human Recombinant Protein
CAT＃: TP701003
Purified recombinant protein of Human chromosome 15 open reading frame 23 (C15orf23), transcript variant 3, mutant (S24F), expressed in HEK293 cells, 20ug
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CNY 6650.00
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
A DNA sequence from TrueORF clone, RC227425, encoding human KNSTRN mutant S24F
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| Tag | C-Myc/DDK |
| Predicted MW | 26.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_001136234 |
| Locus ID | 90417 |
| UniProt ID | Q9Y448 |
| Cytogenetics | 15q15.1 |
| Refseq ORF | 723 |
| Synonyms | C15orf23; HSD11; SKAP; TRAF4AF1 |
| Summary | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC409608 | KNSTRN HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
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| LC428260 | KNSTRN HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
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| LC428261 | KNSTRN HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY409608 | Transient overexpression lysate of chromosome 15 open reading frame 23 (C15orf23), transcript variant 1 |
CNY 3080.00 |
|
| LY428260 | Transient overexpression lysate of chromosome 15 open reading frame 23 (C15orf23), transcript variant 2 |
CNY 3080.00 |
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| LY428261 | Transient overexpression lysate of chromosome 15 open reading frame 23 (C15orf23), transcript variant 3 |
CNY 3080.00 |
|
| PH322981 | C15orf23 MS Standard C13 and N15-labeled recombinant protein (NP_150628) |
CNY 19520.00 |
|
| TP322981 | Recombinant protein of human chromosome 15 open reading frame 23 (C15orf23), transcript variant 1, 20 µg |
CNY 2900.00 |
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