TNF alpha (TNF) (NM_000594) Human Recombinant Protein
CAT＃: TP721025
Purified recombinant protein of Human tumor necrosis factor (TNF)
View other "TNF alpha" proteins (11)
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CNY 1800.00
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CNY 1999.00
CNY 2700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence |
Gly57-Leu233
|
| Tag | N-His |
| Predicted MW | 21.8 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 um filtered solution of 20mM PB.100mM NaCl, pH8.0. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Reference Data | |
| RefSeq | NP_000585 |
| Locus ID | 7124 |
| UniProt ID | P01375 |
| Refseq Size | 1686 |
| Cytogenetics | 6p21.33 |
| Refseq ORF | 699 |
| Synonyms | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F |
| Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020] |
| Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus |
Documents
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Resources
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC424626 | TNF HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY424626 | Transient overexpression lysate of tumor necrosis factor (TNF superfamily, member 2) (TNF) |
CNY 3080.00 |
|
| PH306983 | TNF MS Standard C13 and N15-labeled recombinant protein (NP_000585) |
CNY 19520.00 |
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| TP306983 | Recombinant protein of human tumor necrosis factor (TNF superfamily, member 2) (TNF), 20 µg |
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|
| TP700015 | Recombinant protein of human soluble form of TNF-alpha with His and DDK tags, expressed in human cells |
CNY 6650.00 |
|
| TP720007 | Recombinant protein of human tumor necrosis factor (TNF superfamily, member 2) (TNF), the soluble form (Val77 -Leu233) |
CNY 3140.00 |
|
| TP721024 | Purified recombinant protein of Human tumor necrosis factor (TNF) |
CNY 1800.00 |
|
| TP723708 | Purified recombinant protein of Human tumor necrosis factor (TNF) |
CNY 4090.00 |
|
| TP723983 | Human TNF alpha Protein, His Tag |
CNY 5249.00 |
|
| TP750007 | Recombinant protein of human Tumor Necrosis Factor-a (TNFa) produced in E. coli. |
CNY 2040.00 |
|
| TP750117 | Purified recombinant protein of Human tumor necrosis factor (TNF) mutant, tag free, expressed in E.Coli, 50 ug |
CNY 2040.00 |
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