CTLA4 (NM_005214) Human Recombinant Protein
CAT＃: TP723874
Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1
View other "CTLA4" proteins (9)
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CNY 2590.00
Product images
CNY 1999.00
CNY 2700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | CHO |
| Expression cDNA Clone or AA Sequence |
Human CTLA-4, the region of Ala37-Phe162, from gene Accession# NM_005214
|
| Tag | Fc chimera |
| Predicted MW | 39.9 kDa |
| Concentration | lot specific |
| Purity | >95%, as determined by Coomassie stained SDS-PAGE |
| Buffer | 1 x PBS |
| Storage | Store at -80°C. |
| Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Bioactivity | Recombinant human CTLA-4 inhibits the production of IL-2 induced by 0.5 μg/mL of CD80 on Jurkat cells in a dose-dependent manner. The ED50 for this effect 50 is 4 - 24 ng/mL. |
| Endotoxin | Less than 0.01 ng per µg protein as determined by the LAL method |
| Reference Data | |
| RefSeq | NP_005205 |
| Locus ID | 1493 |
| UniProt ID | P16410 |
| Refseq Size | 1997 |
| Cytogenetics | 2q33.2 |
| Refseq ORF | 669 |
| Synonyms | ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12 |
| Summary | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC417438 | CTLA4 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421970 | CTLA4 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY417438 | Transient overexpression lysate of cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1 |
CNY 3080.00 |
|
| LY421970 | Transient overexpression lysate of cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 2 |
CNY 3080.00 |
|
| TP700216 | Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells |
CNY 6650.00 |
|
| TP700217 | Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1, with C-terminal human Fc and his tags, expressed in human cells |
CNY 6650.00 |
|
| TP721230 | Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1 |
CNY 1800.00 |
|
| TP723940 | Human CTLA-4 Protein, mFc-His Tag |
CNY 5552.00 |
|
| TP724014 | Human CTLA-4 Protein, hFc tag |
CNY 4925.00 |
