ACE2 Human Recombinant Protein (Angiotensin Converting Enzyme 2)

Specifications

Product Data
Species	Human
Protein Source	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) 18-740
Tag	C-hFc
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human ACE2 Protein is produced by HEK293. The target gene encoding 18-740 is expressed with a hFc tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	59272
UniProt ID	Q9BYF1
Synonyms	Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-ConvertingEnzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Summary	Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensin I and II as a carboxypeptidase and converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor do not inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Renin-angiotensin system

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