PIGR Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) K19-R638
Tag	C-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Biotinylated Recombinant Human Polymeric Immunoglobulin Receptor is produced by Human 293 Cells. The target gene encoding K19-R638 is expressed with a 8His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	5284
UniProt ID	P01833
Synonyms	Polymeric Immunoglobulin Receptor; PIgR; Poly-Ig Receptor; Hepatocellular Carcinoma- Associated Protein TB6; PIGR
Summary	Polymeric Immunoglobulin Receptor (pIgR) is a type I transmembrane glycoprotein. pIgR is expressed by secretory epithelial cells with five Ig-like domains in the extracellular region, and transfer to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs and separates the extracellular (known as the secretory component) from the transmembrane segment.
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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