NFkB p100 / p52 (NFKB2) Human siRNA Oligo Duplex (Locus ID 4791)
CAT#: SR303162
NFKB2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 1,500.00
CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001077493, NM_001077494, NM_001261403, NM_001288724, NM_001322934, NM_001322935, NM_002502, NR_048560 |
Synonyms | LYT-10; LYT10; p52 |
Components | NFKB2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 4791)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability
,null,
Biomedicines
,PubMed ID 35625776
[NFKB2]
|
RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model
,Thomas-Jardin, SE;Dahl, H;Kanchwala, MS;Ha, F;Jacob, J;Soundharrajan, R;Bautista, M;Nawas, AF;Robichaux, D;Mistry, R;Anunobi, V;Xing, C;Delk, NA;,
Prostate
,PubMed ID 31730277
[NFKB2]
|
Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice
,Guicciardi, ME;Krishnan, A;Bronk, SF;Hirsova, P;Griffith, TS;Gores, GJ;,
Cell Death Dis
,PubMed ID 28055006
[NFKB2]
|
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