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Posts for 10/2023
ST2: Potential Biomarker For Cardiovascular Disease
Oct 07, 2023
The ST2 gene (also known as IL1RL1) is a potential biomarker of poor prognosis in cardiovascular diseases. ST2 is present in two important isoforms: Membrane-bound ST2 (ST2L) and soluble ST2 (sST2). ST2L binds with IL33 and has a cardioprotective effect like decreased cardiac damage, prevention of apoptosis, lowered inflammatory effect, hypertrophy, and fibrosis. However, the binding of sST2 to IL33 causes the protective effect to disappear. Elevated levels of soluble ST2 are seen in the pericardial fluid and plasma...
