TDP43 (TARDBP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC/IF, IHC, WB
Recommend Dilution	ELISA, Western Blot: 0.5-2 ug/ml, Immunohistochemistry: 1:250, Immunohistochemistry-Paraffin: 1:250, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000
Reactivity	Human, Primate, Mouse, Xenopus, Zebrafish, Chicken
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein. [Swiss-Prot# Q13148]
Formulation	Tris-glycine, 150mM NaCl and 0.05% sodium azide
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TAR DNA binding protein
Database Link	NP_031401 Entrez Gene 230908 MouseEntrez Gene 23435 Human UniProt ID Q13148
Background	The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap.
Synonyms	ALS10; TDP-43
Reference Data
Protein Families	Transcription Factors

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