GSK3 alpha (GSK3A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 458-467 amino acids of Human glycogen synthase kinase 3 alpha
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	glycogen synthase kinase 3 alpha
Database Link	NP_063937 Entrez Gene 2931 Human UniProt ID P49840
Background	This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase; and transcription factors; such as JUN. It also plays a role in the WNT and PI3K signaling pathways; as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling; regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.
Synonyms	DKFZp686D0638
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Chemokine signaling pathway

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