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IDE Rabbit Polyclonal Antibody
CAT＃: TA323992S
Anti-IDE Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 4,840.00
Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB: 500-2000 WB positive control: K562 cells |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a C terminal 300 amino acids of human insulin-degrading enzyme |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 118 kDa |
| Gene Name | insulin degrading enzyme |
| Database Link | |
| Background | This gene encodes a zinc metallopeptidase that degrades intracellular insulin; and thereby terminates insulins activity; as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon; amylin; bradykinin; and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space; cell membrane; peroxisome; and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. |
| Synonyms | INSULYSIN |
| Reference Data | |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Alzheimer's disease |
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Rabbit anti-IDE Polyclonal Antibody
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