Cyclophilin A (PPIA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human PPIA
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	peptidylprolyl isomerase A
Database Link	NP_066953 Entrez Gene 25518 RatEntrez Gene 268373 MouseEntrez Gene 5478 Human UniProt ID P62937
Background	Cyclophilins are a highly conserved family of peptidylprolylcis-trans-isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines. As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection There is also some evidence that cyclophilins have nuclease activity and play a role in apoptosis.
Synonyms	CYPA; CYPH; HEL-S-69p
Reference Data

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