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SPSB1 (NM_025106) Human Untagged Clone
CAT＃: SC110780
SPSB1 (untagged)-Human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1)
CNY 2,400.00
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SSB-1; SSB1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110780 sequence for NM_025106 edited (data generated by NextGen Sequencing)
ATGGGTCAGAAGGTCACTGGAGGGATCAAGACTGTGGACATGAGGGACCCCACGTACAGG CCCCTGAAGCAGGAGCTCCAGGGTCTGGATTACTGCAAGCCCACCCGGCTGGATCTGCTA CTGGACATGCCCCCTGTGTCCTATGATGTCCAGCTGCTGCATTCATGGAACAACAACGAC CGATCGCTCAATGTCTTTGTAAAGGAGGACGACAAGCTCATCTTTCACCGGCATCCGGTG GCCCAGAGCACGGACGCTATCAGGGGCAAAGTCGGGTATACCCGTGGGCTGCACGTGTGG CAGATCACGTGGGCCATGAGACAGCGGGGCACACACGCCGTGGTGGGGGTGGCGACGGCA GACGCCCCCCTGCACTCTGTCGGGTACACAACCCTCGTGGGGAATAACCACGAGTCCTGG GGCTGGGACTTGGGGCGCAACCGGCTCTACCACGATGGCAAGAACCAGCCAAGCAAAACA TACCCAGCCTTTCTGGAACCAGATGAGACATTCATTGTCCCTGACTCCTTCCTGGTAGCC CTGGACATGGACGACGGGACTCTGAGCTTCATTGTGGATGGACAGTACATGGGAGTGGCT TTTCGGGGACTCAAGGGCAAAAAACTGTATCCTGTAGTGAGTGCCGTCTGGGGCCACTGT GAGATCCGAATGCGCTACTTGAACGGACTCGATCCCGAGCCGCTGCCGCTCATGGATTTG TGCCGTCGCTCGGTGCGCCTGGCCCTGGGGAGGGAGCGCCTGGGGGAGATCCACACGCTG CCGCTGCCGGCTTCCCTCAAGGCCTACCTCCTCTACCAGTGA Clone variation with respect to NM_025106.3 201 g=>a >OriGene 5' read for NM_025106 unedited
TAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTCTCCTGGCAGCCCTCA TTAGGAATTCTGTCTGGCCCCGATCAGAATACTGGAGACGAGACCACGAGATTGATGAGT TTGCCTTGGGAGTCGGTAAGAAGGTGAAGCCAGGGGCGAACATGGGTCAGAAGGTCACTG GAGGGATCAAGACTGTGGACATGAGGGACCCCACGTACAGGCCCCTGAAGCAGGAGCTCC AGGGTCTGGATTACTGCAAGCCCACCCGGCTGGATCTGCTACTGGACATGCCCCCTGTGT CCTATGATGTCCAGCTGCTGCATTCATGGAACAACAACGACCGATCGCTCAATGTCTTTG TAAAGGAGGACGACAAGCTCATCTTTCACCGGCATCCGGTGGCCCAGAGCACGGACGCTA TCAGGGGCAAAGTCGGGTATACCCGTGGGCTGCACGTGTGGCAGATCACGTGGGCCATGA GACAGCGGGGCACACACGCCGTGGTGGGGGTGGCGACGGCAGACGCCCCCCTGCACTCTG TCGGGTACACAACCCTCGTGGGGAATAACCACGAGTCCTGNGGCTGGGACTTGGGGCGCA ACCGGCTCTACCACGATGGCAAGAACCAGCCAAGCAAAACATACCCAGCCTTTCTGGAAC CAGATGAGACATTCATTGTCCCTGACTCCTTCCTGGTAGCCCTGGACATGGACGACGGGA CTCTGAGCTTCATTGTGGATGGACAGTACATGGGAGTGGCTTTTCGGNGACTCAAGGGCA NAAACTGTATCCTGTANTGAGTGCCGTCTGGGCCACTGTGAGATCCGATGCGCTACTTGA ACGACTCGATCCCGACCGCTGCCGCTCATGGATTGTGCCCGTCGCTCGTGCGCTGGNCCT GGGNAGGGGACGCCTGGGGGAGATCACCGCTGCCCC >OriGene 3' read for NM_025106 unedited
NCCCTTCTCTGNNACCGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTGATA TTTTAACAAACGTTCCTTTATTAGGTTACTGACTATTATCAACCATCATAAAATAGAACG GGAGTTTCAAAACTGTACAAGCCACAAGGCTCTGGGCTGGTAGGAAAGAAGGGTGGGGTC GAGGGTCCCAGGGTGTCGGGGGGTGGGAGATGCAGAGAGAGCTAGAGGGTCACCCGGCAT CTGTGAGGACGGCTGGGTCAAGGCCATAAGCTGGGATCTGTACAAGGGAAACATTCATCA GAATGTGACCCACCTGAAACAGGAGGGAGGAAAATCTTTAAAAGTCTTACAGGTAAGGTC CCCTGCCCCGAAAAAAAAAACCGTCAAAATAATAAGGGGGTAATGTACATTTCTCACCCA GTCTTGGCACCAATTTTGTGCTTTAAAAAATATACTCCACTGTAAGATTTACTTAAAAAA AGGTACTCTACAGCAGCTGTTTAAAACATAATTCTTACAGACAAATATATATATATGTAT GTATATATATTAAACATTTTAAACAAATAAAGTCATCTATTGTACCTGTGCAGAAATGAA CCAAAGTTAGACTCTAAGAGAGTTAACTTCAAGCTCAAAGAAATGGCAAAGGCGGTGGCA GGTGCTGGGGTACGCTACGTGGAGGGGTTGCCAGGGATAGGGCACCCCTCTCTTTNCGCA GCCGAGCTACCCCTCTTTGAGCTCTGANAGGGGGTNGGGATGAACTGNNGCTGTTACCCC TGGTCCANAGCCCCNGCTGGGGTGCTGAGCANAGACCGCGCTGGCTTCTGTGAGGCTCGA CTCTGCTCTTGGTCTTCCCATCCCACCTGCCCNTGCTCTCGGGGAATGAGACCCCTCGCC TCCTTCTAGTCTGGGGGCCTCTGCCCACCAGAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_025106 |
| Insert Size | 2890 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_025106.2, NP_079382.2 |
| RefSeq Size | 3081 bp |
| RefSeq ORF | 822 bp |
| Locus ID | 80176 |
| UniProt ID | Q96BD6 |
| Domains | SPRY |
| Protein Families | Druggable Genome |
| Gene Summary | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203673 | SPSB1 (Myc-DDK-tagged)-Human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) |
CNY 2,400.00 |
|
| RC203673L3 | Lenti ORF clone of Human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203673L4 | Lenti ORF clone of Human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1), mGFP tagged |
CNY 5,890.00 |
|
| RG203673 | SPSB1 (tGFP-tagged) - Human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) |
CNY 4,000.00 |
