Human PION (GSAP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GSAP
Locus ID	54103
Kit Components	GA110062G1, PION gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110062G2, PION gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110062G3, PION gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_017439, NM_001350896, NM_001350897, NM_001350898, NM_001350899, NM_001350900, NM_001350901, NR_146938, NR_146937
Synonyms	PION
Summary	Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]

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