Protein phosphatase inhibitor 1 (PPP1R1A) (NM_006741) Human Mass Spec Standard

Specifications

Product Data
Description	PPP1R1A MS Standard C13 and N15-labeled recombinant protein (NP_006732)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205263
Predicted MW	18.9 kDa
Protein Sequence	Sequence Link (showhide) >RC205263 protein sequence Red=Cloning site Green=Tags(s) MEQDNSPQKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQ RKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECI PKTHERGSKEPSTKEPSTHIPPLDSKGANSV TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_006732
RefSeq Size	1849
RefSeq ORF	513
Synonyms	I1; IPP1
Locus ID	5502
Cytogenetics	12q13.2
Summary	Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome
Protein Pathways	Long-term potentiation

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