RANKL (TNFSF11) (NM_003701) Human Recombinant Protein
CAT＃: TP723867
Purified recombinant protein of Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11 / RANKL), transcript variant 1
View other "RANKL" proteins (8)
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CNY 5240.00
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence |
Human TRANCE, the region of Gly136-Asp317, from gene Accession# NM_003701
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| Tag | N-His |
| Predicted MW | 22.7 kDa |
| Concentration | lot specific |
| Purity | >95%, as determined by Coomassie stained SDS-PAGE. |
| Buffer | 1 x PBS, pH 6.5 |
| Storage | Store at -80°C. |
| Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Bioactivity | Bioactivity was measured by its property to induce osteoclast differentiation in RAW264.7 cells in the presence of 2.5 µg/ml of anti-His tag antibody (Cat. No. 652501). |
| Endotoxin | Less than 0.01 ng per µg protein as determined by the LAL method |
| Reference Data | |
| RefSeq | NP_003692 |
| Locus ID | 8600 |
| UniProt ID | O14788 |
| Refseq Size | 2226 |
| Cytogenetics | 13q14.11 |
| Refseq ORF | 951 |
| Synonyms | CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE |
| Summary | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC401221 | TNFSF11 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC403220 | TNFSF11 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY401221 | Transient overexpression lysate of tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 1 |
CNY 3080.00 |
|
| LY403220 | Transient overexpression lysate of tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2 |
CNY 3080.00 |
|
| PH318782 | TNFSF11 MS Standard C13 and N15-labeled recombinant protein (NP_003692) |
CNY 14250.00 |
|
| PH324778 | TNFSF11 MS Standard C13 and N15-labeled recombinant protein (NP_143026) |
CNY 19520.00 |
|
| TP318782 | Purified recombinant protein of Homo sapiens tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 1, 20 µg |
CNY 2900.00 |
|
| TP324778 | Recombinant protein of human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2, 20 µg |
CNY 2900.00 |
Rabbit anti-TNFSF11 Polyclonal Antibody
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